Yes, SapphreIMS supports version 4.6 and 5.0 of MS application virtualization (App-V) client for inventory collection. SapphireIMS supports this using WMI data collection mode for both agent and agent-less. It can configured for software compliance and software metering.
Point to note is as there is no underlying change in WMI on 5.x version of App-V, SapphireIMS should support this version as well.
Please refer Discovery_viewing and click on Software->App-V data collection for more details.